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Monitoring Schedule Serum IGF-1 at baseline and at 8-12 weeks Fasting glucose at baseline and every 3-6 months (GH increases insulin resistance acutely) Thyroid panel at baseline (hypothyroidism blunts IGF-1 response) Blood pressure and fluid retention assessment at each visit The American Association of Clinical Endocrinology (AACE) recommends IGF-1 be kept within the age- and sex-adjusted reference range during any GH-stimulating therapy to minimize risk of adverse effects including fluid retention and glucose intolerance [9]

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On balance, the public-private hybrid model addresses some of the challenges in the private-market intermediation model, and it merits consideration by policymakers as a next step

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IGF2BPs are increasingly recognized as pivotal epigenetic readers that preferentially bind to methylation-modified mRNA, thereby facilitating cancer progression [30]